Just recently, the "Unrevoked" one click rooting program became available from http://unrevoked.com.
The "Unrevoked" root won't run on a Windows 7 64 bit out of the box, on an HTC desire, because of a missing driver. This can be easily fixed in a few steps.
Luckily, the Android SDK drivers have a 64 bit version of the ABI driver. The problem is, that the USB identification of the device is unknown to the driver. To fix it, we need to add the following line to the "android_winusb.inf" file:
[Google.NTamd64]
%SingleBootLoaderInterface% = USB_Install, USB\VID_0BB4&PID_0C94&REV_0100
This line defines that on a 64 bit machine, if the USB device with a vendor ID of 0x0BB4 (HTC) and a product ID of 0x0C94 (Bootloader interface on HTC Desire), then the driver that should be installed is "%SingleBootLoaderInterface%".
After that, install the driver you altered and that's it.
This is how the USB driver identifies itself (when the driver is not installed, you can look at the hardware IDs of the device identified as "Android 1.0" (which is the bootloader interface before the driver is installed).
Just right click the driver, click Properties, go to Details, and look at the "Hardware Ids" section. You can do the same trick for any other Android device which supports ABI.